I doubt anyone is going to put this board in a serious gaming machine, but one fan is the bare minimum cooling for even an Internet & light officework PC. And, really, it's pretty lazy of Asus to not include this F_PANEL pinout in the manual instead of, heh, phoning it in: PWR PWR PWR PWR LED LED...
Low cost Runs fine
Only one case fan power header Lazy manual doesn't have F_PANEL pinout