I have used computers for 35 years and also have a very large hand (Can pickup a basket ball with one hand) Due to years of mouse and digetising I have occupational over use syndrome in right wrist and can not use a standard mouse for more than an hour. Previously used Contour extra large mouse imported from US. However recently struggled to get replacement from US. So purchased the large evoluent mouse as replacement. Took a little getting use to, but now love it and do not get sore wrist and would recommend it to anyone who suffers from OOUS.