Between Sony's MDR-1000x and the Bose Q35, its my opinion that Sony takes the cake. Testing both out in a noisy electronics store (music playing in the back ground, PA making announcements, people talking, etc) There was extreme background silence with Sony's Noise cancelling system.
Outstanding noise cancelling; rich; full sound
Ear drums can ache at times...and not due to loud play back but possibly sound wave compression due to such a tight seal around the ears (this is my untrained ear's opinion) Wife did not experience this; and I do not every time; just a couple times so far.