After using this keyboard at home for a month, I talked my boss into getting the company buy one for me at work. Since, I have had no problems with my wrists or hands hurting. I am very impressed with the Microsoft Natural Ergonomic Keyboard 4000. In fact, many co-workers also wanted the keyboard.
Padded wrist wrest; Great ergonomic design; Programmable keys
Keys are soft; touch typists might not like